SATURDAY, MARCH 18

Salon B/C Foyer

Salon B/C Foyer

4:00 pm - 5:30 pm

ASN Public Policy Forum: Alzheimer's and You

Chairs: Sue Griffin, PhD - University of Arkansas for Medical Sciences  

& Steve Barger, PhD - University of Arkansas for Medical Sciences

This Forum will focus on the patient – disease progression and brain changes accompanying cognitive decline; on the caregivers - stress, fatigue, and out-of-pocket costs; and on research – treatment and prevention successes and failures.

1. Introduction to Alzheimer’s Disease, with Broad Stroke Assessment of Brain Changes and the Impact of Dementia in a Small Southern State - Arkansas - Sue Griffin, PhD, University of Arkansas for Medical Sciences 
2. National Impact of Alzheimer’s and its Care - Susan Neyman, Alzheimer’s Association, Arkansas
3. The Importance of Community Actions and Statewide and Local Outreach to Patients, Caregivers, and Activists - Elise Siegler, Alzheimer’s Arkansas and Claudia Beverly, PhD, RN, FAAN, Hartford Center of Geriatric Nursing Excellence and The Arkansas Aging Initiative at the University of Arkansas for Medical Sciences 

4. Where We Are in Scientific Advances Toward Treatment and Prevention of Alzheimers - Steve Barger, PhD, University of Arkansas 

Conway

6:00 pm - 7:30 pm

ASN President's Welcome Reception                         
Hosted by     Sponsored by           

Salon A

SUNDAY, MARCH 19

7:00 am - 6:00 pm

 ASN Registration Desk Open

Salon B/C Foyer

8:15 am - 8:30 am

President’s Welcome & Introductions
New Member Recognition / YIEE Award Recognition

Salon A

8:30 am - 9:30 am

Presidential Lecture 01:  
Circuit Assembly and Reassembly in the Retina
 
Rachel Wong, PhD - University of Washington
Chair: Doug Feinstein

Salon A

9:30 am - 10:00 am

Coffee Break: View Posters & Visit Exhibits  

Salon B/C & Foyer

10:00 am - 12:00 pm

Plenary Lecture PL01: 
Glial-Glial Interactions in Development & Disease
Jordi Folch-Pi Memorial Lecture

Chair: Sarah Kucenas, University of Virginia

1. Adenosine signaling mediates glial segregation at the motor exit point transition zone - Sarah Kucenas, University of Virginia
2. How do astrocytes develop a complex morphology and attain their synaptogenic function? - Jeff Stogsdill, Duke University Medical Center
3. Homeostatic Interactions Among Oligodendrocyte Precursor Cells (OPCs) in Health and Diseases - Hui Zong, University of Virginia
4. The Glide/Gcm fate determinant controls initiation of collective cell migration by regulating Frazzled - Angela Giangrande, France Université de Strasbourg

Salon A

12:15 pm - 1:30 pm

 Lunch with Presidential Speaker: Rachel Wong, PhD         
        Ticket Required ($15) - Limited to 20 Student/Post Docs

Hoffman

1:30 pm - 3:30 pm

Sponsored by

S01 - Proteolipid Protein: Are You Better With It or Without It?

Chair: Robert Skoff, Wayne State University

1. Myelin devoid of proteolipid protein impacts brain function in young adult mice - Wendy Macklin, University of Colorado
2. What makes PLP1 gene expression tick? - Patricia Wight, University of Arkansas
3. Prospect for stem cell approaches in the treatment of demyelinating leukodystropies - Anne Baron-Van Evercooren, Pierre and Marie Curie University
4. The absence of proteolipid protein isneuroprotective in neonatal hypoxic ischemic mice - Robert Skoff, Wayne State University

Salon A

1:30 pm - 3:30 pm

Sponsored by

S02 - Lipid Metabolism in Neural Stem Cells, Brain Development & 
Function

Chair: Guanghu Wang, Medical College of Georgia at Augusta University 

1. Lipid Metabolism in Adult Neural Stem Cell Biology and Alzheimer's Disease - Karl Fernandes, Université de Montréal
2. The blood brain barrier and fatty acid uptake: Role of the BBB as a metabolic barrier? - Eric Murphy, University of North Dakota
3. Deoxysphingolipids as taxanes neurotoxic mediators in the peripheral nervous system - Stefanka Spassieva, Texas A&M Health Sciences Center
4. Ceramide Regulates Cilia Formation in Human Neural Progenitor Cells and Murine Ependymal Cells - Guanghu Wang, Medical College of Georgia at Augusta University

Conway

3:30 pm - 4:00 pm

Coffee Break: View Posters & Visit Exhibits

Salon B/C & Foyer

C01 - Traumatic Brain Injury Affects Neurovascular Unit Function

Chair: Stefanie Robel, Virginia Tech Carilion Research Institute

1. Blast-related mild traumatic brain injury: The consequences of more than a decade at war - David Cook, University of Washington
2. Damaged astrocytes affect neurovascular unit function after repeated mild traumatic brain injury/concussion - Stefanie Robel, Virginia Tech
3. Interogation of collateral vessel remodeling following traumatic brain injury - Michelle Theus, Virginia Tech

Salon A

C02 - Chewing the Fat about Chewing the Fat: Interactions of Diet 
and Digestion with Cognition             

Chair: Steve Barger, Univ. Arkansas for Medical Sciences 

1. Amyloid Precursor Protein Impacts on Peripheral Metabolism: Potential for Indirect Effects on CNS - Steve Barger, Univ. Arkansas for Medical Sciences
2. Characterizing Alzheimer's Disease in the Enteric Nervous System - Colin Combs, University of North Dakota
3. Surprising Sources of CNS Inflammation - Annadora Bruce-Keller, Louisiana State University

Conway

4:00 pm - 5:30 pm

OR01 - Oral Session I: Presentation of Selected Abstracts

1. Sox17 Regulates Sox2 and Tcf7L2/Tcf4 Induction, and Promotes Oligodendrocyte Progenitor Response to Demyelination - Li-Jin Chew
2. Protofibrillar Amyloid-Beta is Preferentially Internalized by Primary Microglia - Lisa Gouwens
3. Optical Interrogation of the Supramolecular Organization of Gap Junctions- How Nexus Structure Regulates Cellular Function of Glia - Randy Stout
4. Acute Neuroinflammation Induces Axon Initial Segment Structural Plasticity - Savannah Benusa
5. Absence of Mtorc2 Signaling in Oligodendrocyte Precursor Cells Hinders Differentiation and Myelination - Hannah Hathaway
6. Nectin-Like 2 (Necl-2) Cell Adhesion Molecule is a Negative Regulator of Schwann Cell Myelination - Ming-Shuo Chen

Harris Brake

5:30 pm - 7:00 pm

Poster Session I - Authors Present                                    
Wine & Cheese Served

Salon B/C & Foyer

  Student / Post Doc Mingle   
        Ticket Required - Limited to Students / Post Docs only
			

MONDAY, MARCH 20

7:00 am - 5:00 pm

 ASN Registration Desk Open

Salon B/C Foyer

General Session - Opening Remarks                                      
Jordi Folch-Pi Award - Presented by Eric Murphy

Salon A

Presidential Lecture 02: 
Promoting Axon Regeneration by Manipulating Intrinsic Growth 
Capacity of Adult CNS Neurons

Zhigang He, PhD - Harvard University

Salon A

9:30 am - 10:00 am

Coffee Break: View Posters & Visit Exhibits

Salon B/C & Foyer

10:00 am - 12:00 pm

Plenary Lecture PL02:  ER Stress and Neurodegeneration

Chairs: Yang Hu, Stanford University & Jonathan Lin, University of California San Diego

1. The Role of ER Protein Misfolding in Neurodegeneration: Potential Therapeutic Approaches - Randal Kaufman, Sanford Burnham Prebys Medical Discovery Institute
2. Mutations in ER Stress Regulator, ATF6, Cause the Photoreceptor Disease Achromatopsia - Jonathan Lin, University of California San Diego
3. The Integrated Stress Response Provides Oligodendrocyte Protection Against CNS Inflammation - Brian Popko, University of Chicago
4. Translational Regulatory Mechanisms in Pathological Learning - Mauro Costa-Mattioli, Baylor College of Medicine

Salon A

  Women in Neurochemistry Lunch                                         
        
        Ticket Required ($25 Faculty / $15 Student)

Arkansas Ballroom

12:15 pm - 1:30 pm

 Lunch with Presidential Speaker: Zhigang He, PhD
        Ticket Required ($15) - Limited to 20 Student/Post Docs

Hoffman

S03 -  Defining Neuropsychiatric Disorders by Using Human 
Induced Pluripotent Stem Cell (iPSC) Technologies                    

Chairs: Emanuel DiCicco-Bloom, Rutgers University & James H. Millonig, Rutgers University 

1. Pluripotent stem cells as model for understanding and treating Fragile X Syndrome - Xinyu Zhao, University of Wisconsin-Madison
2. Generating idiopathic autism iPSCs to characterize individual-specific mechanisms of disease - James H. Millonig, Rutgers University
3. Abnormalities in proliferation, differentiation and cell migration cluster in idiopathic autism - Emanuel DiCicco-Bloom, Rutgers University
4. Developing 3D human brain models to study development and disease - Sergiu Pasca, Stanford University

Salon A

S04 - ApoE as an AD Therapeutic Target: Novel Approaches

Chairs: Mary Jo LaDu, University of Illinois at Chicago & Leon Tai, University of Illinois at Chicago 

1. ApoE4-containing lipoproteins in the CNS: "Repurposing" drugs from the cardiovascular field - Mary Jo LaDu, University of Illinois at Chicago
2. APOE4 modulated cerebrovascular dysfunction as a potential therapeutic target for Alzheimer's disease - Leon Tai, University of Illinois at Chicago
3. Mimetics of apolipoprotein-E as a novel therapeutics for Alzheimer's Disease and Cancer - Michael P. Vitek, Duke University
4. Anti-inflammatory rescue of APOE4-related phenotypes - G. William Rebeck, Georgetown University

Conway

Coffee Break: View Posters & Visit Exhibits

Salon B/C & Foyer

C03 - Major Advancements in Your PhD Career

Chairs: Haley Titus, Northwestern University & Joshua Burda, UCLA

1. Young Investigators Funding Opportunities Session - Sanoj Suneja, National Institute on Aging/NIH/DHHS
2. How to Find a Good Postdoctoral Position Fit - Joshua Burda, UCLA & Haley Titus, Northwestern University
3. Applying for a Job in Academia - Monica Carson, University of California, Riverside
4. Successful Transitioning from Academia to Industry - Karen Chandross, Sanofi 
5. Write Well and Review Constructively - Scott Brady, University of Illinois, Chicago

Salon A

4:00 pm - 5:30 pm

C04 - Glial-Neuronal Interactions in Epileptogenesis

Chairs: Thimmasettappa Thippeswamy, Iowa State University & Devin Binder, University of California, Riverside

1. The Role of Astroglial Glutamine Synthetase in Health and Disease - Tore Eid, Yale University
2. Targeting immune and vascular signaling after brain injury to limit epileptogenesis - Vijaylakshmi Santhakumar, Rutgers University
3. Role of astrocyte channels and transporters in epileptogenesis - Devin Binder, University of California, Riverside
4. Neuroinflammation mediators as targets for disease modification in epilepsy - Thimmasettappa Thippeswamy, Iowa State University

Conway

C05 - Neuropathologic Mechanisms, Consequences, and Intervention 
in Fetal Alcohol Spectrum Disorders

Chairs: Sandra Mooney, University of Maryland & Cynthia Kane, University of Arkansas

1. Overview of FASD - Antonio Noronha, NIAAA
2. Plasma microRNAs during pregnancy predict variations in infant outcomes due to prenatal alcohol expo - Rajesh Miranda, Texas A&M University
3. Developmental stage-dependent effects of early gestational ethanol exposure: Neuroimaging - Scott Parnell, University of North Carolina
4. Prenatal ethanol exposure alters brain structure and behavior: Can nutritional interventions improve outcomes? - Sandra Mooney, University of Maryland
5. Alcohol-induced neuroinflammation in fetal alcohol spectrum disorders and potential intervention - Cynthia Kane, University of Arkansas

Harris Brake

 ASN Business Meeting

Salon A

TUESDAY, MARCH 21

ASN Registration Desk Open

Salon B/C Foyer

General Session - Opening Remarks  
Marion Kies Award - Presented by Astrid Cardona and Emma Wilson

Salon A

8:30 am - 9:30 am

Presidential Lecture 03: 
Immunosuppression Regulates Amino Acid Metabolism in the 
Brain: Implications for Alzheimer's Disease
George Siegel Basic Neurochemistry Textbook Lecture

Carol Colton, PhD - Duke University
Chairs: George Siegel & Scott Brady

Salon A

9:30 am - 10:00 am

Coffee Break: View Posters & Visit Exhibits

Salon B/C & Foyer

10:00 am - 12:00 pm

Sponsored by

Plenary Session PL03:  Tubulinopathies and Related Disorders 

Chair: Judy Liu, George Washington University 

1. Tubb4a and Myelination in the Mouse - Karel Liem, Yale University
2. Regulation of Microtubule Function in Neurons by Acetylation at Novel Sites - Jill Kathleen Wildonger, University of Wisconsin
3. TUBB4A mutations are associated with mutation specific cell selective abnormalities - Quasar Padiath, University of Pittsburgh
4. Deletion of TUBB3 delays peripheral axon regeneration - Long Cheng, Harvard University

Salon A

 Lunch with Presidential Speaker: Carol Colton, PhD             
        Ticket Required ($15) - Limited to 20 Student/Post Docs

Hoffman

ASN 2018 Planning Committee Meeting

Manning

S05 - Regulation of Mitochondrial Metabolism: New Insights & 
Mechanisms

Chairs: Mary McKenna, Univ. of Maryland & Arne Schousboe, Univ. of Copenhagen

1. Flexible fueling: Investigating hippocampal primary neuron resiliency to  metabolic challenges - Courtney Sobieski, Washington University
2. Succinylation by the alpha-ketoglutarate dehydrogenase complex alters enzyme function and varies with metabolic state - Gary Gibson, Cornell University
3. Visualization of NAD+ and NADH in human brain - Wei Chen, University of Minnesota
4. Exploring the role of NAMPT-mediated NAD+ biosynthesis in mitochondrial function and energy metabolism - Jun Yoshino, Washington University

Salon A

1:30 pm - 3:30 pm

Sponsored by

S06 - Interacting Signaling Pathways at the Crossroads to 
Demyelinating and Remyelinating Responses                                     

Chair: Bridget Shafit-Zagardo, Albert Einstein College of Medicine & Cheryl Dreyfus, Rutgers University

1. Inducible Genetic Fate Labeling for In Vivo Detection of Sonic Hedgehog Signaling During Corpus Callosum Myelination in Postnatal Development and Following Chronic Demyelination - Regina Armstrong, Uniformed Services University of the Health Sciences
2. Extensive axonal damage and demyelination are observed in Gas6-/-Axl-/- double-knockout (DKO) mice following demyelination - Bridget Shafit-Zagardo, Albert Einstein College of Medicine
3. TrkB on oligodendrocytes directly mediates BDNF"s effects on myelin following a demyelinating lesion - Cheryl Dreyfus, Rutgers University
4. Loss of TSC1 in Adult OPCs Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination - Teresa Wood, Rutgers University

Conway

Coffee Break: View Posters & Visit Exhibits

Salon B/C & Foyer

C06 - Roles of Lipids in Neurological Disorders

Chairs: Xianlin Han, Sanford Burnham Prebys Medical Discovery Institute & Xiao-Ming Xu, Indiana University 

1. Phospholipase A2 as a novel target for neuroprotection after spinal cord injury - Xiao-Ming Xu, Indiana University
2. Bis(monoacylglycero) phosphate as a secondary storage lipid in the gangliosidoses - Zeynep Akgöç, Boston College
3. Activity of Water Channel Protein in Post-traumatic Syringomyelia Formation - Christopher B. Shields, Norton Neuroscience Institute
4. Loss of sulfatide: The key node leading to the pathogenesis of Alzheimer's Disease - Xianlin Han, Sanford Burnham Prebys Medical Discovery Institute

Salon A

4:00 pm - 5:30 pm

Sponsored by

C07 - Cellular and Molecular Mechanisms of Peripheral Myelin 
Homeostasis During Development and in Diseases

Chairs: Haesun Kim, Rutgers University  & Corey Heffernan, 

1. Proteostasis in Normal and Diseased Myelinating Schwann Cells - Lawrence Wrabetz, Buffalo University
2. Cholesterol homeostasis in neuropathic Schwann cells - Lucia Notterpek, University of Florida
3. Choline and lipid homeostasis in PNS myelination - Corey Heffernan, Rutgers University
4. Abnormal Myelin Permeability in PMP22 Deficiency - Jun Li, Vanderbilt University

Conway

OR02 - Oral Session II: Presentation of Selected Abstracts  

1. Partial Rescue of Rett Syndrome Phenotypes via Modulation of Nf-Κb Signaling and Vitamin D Supplementation in Mecp2-Null Mice - Jessica MacDonald
2. Lrrtm1 Contributes to the Assembly of Complex Retinogeniculate Synapses in Mouse Visual Thalamus - Aboozar Monavarfeshani
3. Mutant Huntingtin Expression Induces Jnk Activation and Promotes Axonal Degeneration in Vulnerable Cortical Neuron
   Subpopulations - Nichole Mesnard-Hoaglin
4. Examination of the Class IV Semaphorin Sema4A in Multiple Sclerosis Pathogenesis - Brian Chiou
5. Klotho Regulates Postnatal Neurogenesis and Protects Against Age-Related Loss of Dentate Gyrus Function - Gwendalyn King 
6. Morphological and Functional Consequences of Hiv-1 Tat on Area Ca1 of the Hippocampus - William Marks

Harris Brake

Poster Session II - Authors Present                                   
Wine & Cheese Served

Salon B/C & Foyer

7:00 pm - 10:00 pm

Neurochemical Research Editorial Board Meeting

Offsite

WEDNESDAY, MARCH 22

General Session - Opening Remarks
ASN Neuro Award - Presented by Monica Carson
Sanofi Award - Presented by Karen Chandross
Biolegend Award - Presented Patrick Zou

Salon A

8:30 am - 9:30 am

Presidential Lecture 04: 
Astrocyte Control of Neural Circuits and Behavior
 
Marc Freeman, University of Massachusetts

Salon A 

Coffee Break & Visit Exhibits / Remove Posters

Salon B/C & Foyer

10:00 am - 12:00 pm

Sponsored by

Plenary Lecture PL04: Strategies for Promoting CNS Remyelination 
in Demyelinating Disorders

Chair: Jeffrey Huang, Georgetown University 

1. Regulation of Inflammation Resolution in CNS Remyelination - Jeffrey Huang, Georgetown University
2. Oligodendrocyte Precursors migrate along vasculature in the developing nervous system - Stephen Fancy, UCSF
3. The Role of Endothelin-1 signaling in oligodendrocyte development and regeneration - Vittorio Gallo, Children's National Medical Center
4. Small molecule inducers of remyelination and their associated mechanisms of action - Luke Lairson, The Scripps Research Institute

Salon A

  ASN Council Meeting II                                                   

Manning

 Lunch with Presidential Speaker: Marc Freeman, PhD
        Ticket Required ($15) - Limited to 20 Student/Post Docs

Hoffman

1:30 pm - 3:30 pm

S07 - Glial Cells of the Second Brain: Novel Roles of Enteric Glia in 
Health and Disease
Marian Kies Symposium

Chair: Vladimir Grubisic, Michigan State University

1. Heterogeneity of enteric glia and neuron-glia interactions in the enteric nervous system - Werend Boesmans, University of Leuven, Belgium
2. Enteric glia actively regulate gut reflexive behaviors such as peristalsis and epithelial functions - Vladimir Grubisic, Michigan State University
3. Vertebrate enteric glial cells: What the Zebrafish can tell us - Sarah McCallum, Francis Crick Institute
4. Where the gut meets the brain - Diego V. Bohorquez, Duke University

Salon A

S08 - Extracellular Vesicles in Neurodegenerative Disease

Chair: Michael B. Dinkins, Augusta University

1. Improvement of Alzheimer's Disease Pathology by Targeting Neutral Sphingomyelinase-2  - Michael Dinkins, Augusta University
2. Microvesicle shedding from microglia and interactions with amyloid-β - Michael Nichols, University of Missouri-St. Louis
3. Extracellular vesicles in Multiple Sclerosis - Maria Irene Givogri, University of Illinois-Chicago
4. Exosome pathway as a new therapeutic target of tau propagation in Alzheimer's Disease - Tsuneya Ikezu, Boston University

Conway

Coffee Break & Visit Exhibits

Salon B/C & Foyer

4:00 pm - 5:30 pm

C08 - Multimodal Approach Targeting Post-Stroke Inflammatory 
Responses for Therapeutic Intervention

Chairs: Surojit Paul, Univ. of New Mexico & Eduardo Candelario-Jalil, Univ. of Florida 

1. Role of brain-enriched tyrosine phosphatase Ptpn5 in regulating neuroinflammation in ischemic stroke - Surojit Paul, University of New Mexico
2. Activation of the liopxinA4 pathway promotes resolution of neuroinflammation after ischemic stroke - Eduardo Candelario-Jalil, University of Florida
3. TREM2 promotes phagocytosis and improved recovery following experimental brain ischemia and trauma - Midori A Yenari, University of California, San Francisco
4. Comorbidity-modified neuroinflammation in ischemic stroke: role of CD36 - Sunghee Cho, Weill Cornell Medicine at Burke Medical Research Institute

Salon A

C09 - Principles of Neurogliopathology

Chairs: Nina Vardjan, University of Ljubljana

1. Glial calcium signalling in neurodegenerative diseases - Vladimir Parpura, University of Alabama Birmingham
2. Live imaging of brain injury depolarizations and their impact on neuroglia - Sergei A. Kirov, Medical College of Georgia
3. Astrocytic calcium- and cAMP-mediated functions in health and diseases - Nina Vardjan, University of Ljubljana
4. Autotaxin: a regulator of oligodendrocyte differentiation and CNS myelination - Babette Fuss, Virginia Commonwealth University

Conway

C10 - Organ-on-a-Chip Technology: Recent Advances & Challenges

Chair: Syed F. Ali, National Center for Toxicological Research & Hector Rosas-Hernandez, National Center for Toxicological Research

1. Human Microphysiological Systems: Tissues-on-Chips for In Vitro Safety, Toxicity and Efficacy Testing - Lucie Low, National Center for Advancing Translational Sciences, NIH
2. High-speed and biaxial stretch as in vitro models of traumatic brain injury to the blood-brain barrier - Hector Rosas-Hernandez, National Center for Toxicological Research
3. Cardiac and neurovascular systems on-a-chip - Kartik Balachandran, University of Arkansas
4. Vascularization of Organ on a Chip Systems - Kapil Pant, CFD Research Corporation SynoVivo, Inc.

Harris Brake

7:30 pm - 10:30 pm

ASN Closing Reception / Dinner / Dancing                
Hosted by  
 
All registered delegates are invited to attend the closing reception.

Clinton Presidential Library